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More strictly to human studies, in 16 breast cancer patients treated for 10 days, bromelain could reduce CD44 expression (similar to above), while augmenting CD11a and CD62L expression (125)

Insulin resistance and hyperglycemia Long term use of IGF-1 LR3 may suppress growth hormone (GH) secretion through negative feedback, leading to decreased insulin sensitivity

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It belongs to the growth hormone secretagogue (GHS) family and, within it, to the growth-hormone-releasing peptide (GHRP) subgroup

Currently, the exploration of OSF has been carried out for half a century and has been mainly focused on etiology and pathogenesis 3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21 (Fig